Safar Lab Publications

Dr. Safar’s research in Nature Medicine is the most cited original paper on prions published in the past 20 years (cited 920-times; Institute for Scientific Information) Safar J. et al., Nature Medicine 1998.

  • 132 journal articles and book chapters

    • Cited (Institute for Scientific Information): 6,588-times

    • Average citations per paper: 56

    • h-index: 36

  • 27 issued patents

Selected Peer Reviewed Articles

  1. Kim C, Xiao X, Chen S, Haldiman T, Smirnovas V, Kofskey D, Warren M, Surewicz K, Maurer NR, Kong Q, Surewicz W, Safar JG. (2018) Artificial strain of human prions created in vitro. Nature Communications 9(1):2166. doi: 10.1038/s41467-018-04584-z. PMCID: PMC5986862.

  2. Cohen ML, Kim C, Haldiman T, ElHag M, Mehndiratta P, Pichet T, Lissemore F, Shea M, Cohen Y, Chen W, Blevins J, Appleby BS, Surewicz K, Surewicz WK, Sajatovic M, Tatsuoka C, Zhang S, Mayo P, Butkiewicz M, Haines JL, Lerner AJ, Safar JG. (2015) Rapidly Progressive Alzheimer Disease Features Distinct Structures of β-Amyloid. Brain: Epub 2015/02/18. PMID: 25688081.

  3. Safar JG, Xiao X, Kabir ME, Chen S, Kim C, Haldiman T, Cohen Y, Chen W, Cohen ML, Surewicz WK. (2015) Structural determinants of phenotypic diversity and replication rate of human prions. PLoS Pathog. 2015 Apr 14;11(4):e1004832. doi: 10.1371/journal.ppat.1004832. eCollection 2015. PMCID: PMC4397081.

  4. Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG. (2014) Prion disease tempo determined by host-dependent substrate reduction. J Clin Invest. 2014; 124(2):847-58. PMCID: PMC3904628.

  5. Haldiman T, Kim C, Cohen Y, Chen W, Blevins J, Qing L, Cohen ML, Langeveld J, Telling GC, Kong Q, Safar JG. (2013) Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection. J Biol Chem. 2013 Oct 11;288(41):29846-61. PMCID: PMC37952833.

  6. Kim, C., Haldiman,T., Surewicz, K., Cohen, Y., Chen, W., Blevins, J., Sy, M-S., Cohen, M., Kong, Q., Telling, G.C., Surewicz, W.K., and Safar, J.G. (2012) Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C). PLoS Pathog. 2012 Aug;8(8):e1002835. Epub 2012 Aug 2. PMCID: PMC3410855.

  7. Safar, J.G., Geschwind, M.D., Deering, C., Didorenko, S., Sattavat, M., Sanchez, H., Serban, A., Vey, M., Baron, H., Giles, K., Miller, B.L., Dearmond, S.J., Prusiner, S.B. (2005) Diagnosis of human prion disease. Proc. Natl. Acad. Sci. U S A.  Mar 1;102(9):3501-6. PMCID: PMC552933.

  8. Safar, J.G., DeArmond, S., Kociuba, K., Deering, D, Didorenko, S., Bouzamondo-Bernstein, E., Prusiner, S.B., Tremblay, P. (2005) Prion clearance in bigenic mice. J. Gen. Virol., 86(Pt 10):2913-23. PMID: 16186247.

  9. Safar, J.G., Scott, M., Monaghan, J., Deering, C., Didorenko, S., Vergara, J., Ball, H., Legname, G., Leclerc, E., Solforosi, L., Serban, H., Groth, D., Burton, D.R., Prusiner, S.B., Williamson, R.A. (2002) Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice. Nature Biotech. 11:1147-50. PMID: 12389035.

  10. Safar, J., Wille, H., Itri, V., Groth, D., Serban, H., Torchia, M., Cohen F.E., Prusiner, S.B. (1998) Eight prion strains have PrPSc molecules with different conformations. Nature Medicine 4: 1157-1165.  PMID: 9771749.

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All PubMed Publications for Safar Lab